The two infamous proteins, amyloid-beta and tau, that characterize advanced Alzheimer's disease, start healthy neurons on the road to cell death long before the appearance of the deadly plaques and tangles by working together to reactivate the supposedly blocked cell cycle in brain cells, according to research presented on Dec. 17 at the American Society for Cell Biology's Annual Meeting in San Francisco. Working in a mouse model, George Bloom, PhD, of the University of Virginia reports that neurons in Alzheimer’s start dying because they break the first law of human neuronal saf...