New research presented at the 12th Biennial Ovarian Cancer Research Symposium held September 13–15 in Seattle advances toward a better understanding of the mechanisms underlying why most patients with high-grade serous ovarian cancer (HGSOC) develop resistance to poly (ADP-ribose) polymerase (PARP) inhibitors, with the aim to eventually find ways to identify patients most likely to overcome resistance and respond to PARP inhibitors. “There are many challenges to studying chemoresistance, and this work addresses a couple of them,” said Charles “Chip” Landen, MD, associate professor of gynecolog...