Patients with high levels of four blood biomarkers may be more likely to have an ischemic stroke than those with low rates of the markers, researchers reported. In an accompanying editorial, Stephen Williams of the University of Virginia and Dr. Svetlana Lorenzano of Sapienza University in Rome agreed that the study "helped refine a well-established stroke risk clinical model ... and helped enhance individual stroke risk prediction," but similarly cautioned that it "should be further assessed in prospective investigations."