For some time now, scientists have believed that allergies, in general, may set off an immunological chain reaction that leads to atherosclerosis, or a buildup of fatty plaque in the arteries that hardens over time, narrowing the blood vessels. However, the mechanisms that underpin this process are not understood. In the new study, researchers at the University of Virginia Health System wanted to dig deeper. So, they devised an experiment to investigate whether individuals with red meat allergies might be more susceptible to atherosclerosis and, if so, why.