Neetu Dahiya, obstetrics and gynecology research associate, "MicroRNA let-7: Role in Human Diseases and Drug Discovery." Nova Publishers.
February 9, 2012 — MicroRNAs are small, non-coding RNAs involved in post-transcriptional regulation of gene expression. Thousands of them have been identified in different organisms, including viruses, insects, plants and animals.
miRNAs have emerged as key regulators of important biological processes. The differential expression of miRNAs in various human diseases has made them potential candidates for developing novel therapies and personalized medicines.
The book focuses on microRNA let-7, the second miRNA, discovered in 2000 and one of the most studied since. Dahiya covers various aspects of miRNA let-7: its discovery, biogenesis, transcriptional and posttranscriptional regulation, and its crucial role in various fundamental cellular processes, such as development, stem-cell maintenance and differentiation, regulation of signaling pathways in cancer, drug resistance and therapeutic potential in different human diseases.