The UVA Medical Center continues to see more and more patients hospitalized with COVID-19 each week, but most of them are either unvaccinated, or immunocompromised. The number of new COVID-19 cases in the state is now in the 3,000s, which is roughly where we were right after Thanksgiving last year. “There is one huge difference, and that is that we now have an effective vaccine,” UVA Health epidemiologist Dr. Costi Sifri said. “And we did not have one in November that was, you know, being used and distributed.”