UVA Health Joins National Trial Testing Medications for Mild to Moderate COVID-19

Microscope looking at a slide with gloved hands holding the slide
February 21, 2022

UVA Health has joined a nationwide study evaluating two repurposed medications in the search for effective, safe treatments for mild to moderate COVID-19. Repurposed medications are already approved by the U.S. Food and Drug Administration for the treatment of other diseases or conditions.

ACTIV-6, “The Randomized Trial to Evaluate Efficacy of Repurposed Medications,” is a nationwide, double-blind study expected to enroll nearly 15,000 participants from across the U.S. A double-blind study means that both study participants and researchers do not know which medication participants are receiving as part of the trial.

Residents from throughout Virginia and across the U.S. can get more information on how to participate in the trial by visiting activ6study.org or calling 833-385-1880. Volunteers in the trial can participate from home.

The study is now testing these repurposed medications:

“While we have some great new drugs for COVID-19 in outpatients, like Paxlovid and sotrovimab, supplies are limited and it’s still important to find potential new treatments,” said Dr. Patrick E.H. Jackson, principal investigator for the clinical trial at UVA Health. “Because the drugs we’re studying are cheap and widely available, they could have a huge global impact if we find they’re effective for COVID treatment.”

Dr. patrick E.H. Jackson Headshot

Eligibility and Trial Participation

To be eligible, participants must be 30 years old or older, have had a positive COVID-19 test within the past 10 days, and have at least two symptoms of the illness for seven days or less. Symptoms include fatigue, difficulty breathing, fever, cough, nausea, vomiting, diarrhea, body aches, chills, headache, sore throat, nasal symptoms, and/or new loss of sense of taste or smell. 

Participation involves taking the medication and keeping track of symptoms over 90 days through online surveys. Medications are shipped at no cost to participants.

The study is part of the National Institutes of Health-funded Accelerating COVID-19 Therapeutic Interventions and Vaccines effort led by the National Center for Advancing Translational Sciences.

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